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The weight-management indication covers adults with a BMI of 30 or above, or a BMI of 27 or above alongside at least one weight-related condition such as hypertension, dyslipidaemia, obstructive sleep apnea, or cardiovascular disease

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The SELECT trial, which included patients with CV disease and overweight or obesity (many also had increased risk for diabetes), showed a reduction in major adverse CV events (defined as CV death, nonfatal heart attack, and nonfatal stroke) of 20% with weekly subcutaneous semaglutide 2.4 mg

Studies have shown that combining it with creatine and leucine may help increase muscle mass and improve physical performance